STEM CELL DIRECTED GENE THERAPY Barbara
نویسندگان
چکیده
1. Abstract 2. Introduction 3. Phenotype of hematopoietic stem cells 4. Sources of hematopoietic stem cells 5. Anti-HIV genes 6. Gene transfer into hematopoietic stem cells 6.1. Retroviral vectors 6.2. Lentiviral vectors 7. Gene expression 8. Clinical trials 8.1. Transfer of an anti-HIV-1 ribozyme into CD34 PBSC from HIV-1-positive adults 8.2. Transfer of an RRE decoy gene into CD34 cells from the bone marrow of HIV-1-positive children 8.3. Transfer of an anti-HIV-1 ribozyme into CD34 PBSC from adults with HIV-1 and lymphoma 8.4. Umbilical cord blood cell trial 9. Perspective 10. References
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